Genes Linked to High Blood Pressure risk

These days, many scientists have been working on research to find more effective treatment for high blood pressure.

Especially, a team from the University of Leicester, working with colleges from the Queen Mary University of London and the University of Cambridge, have found ‘31 gene areas’ which seems to related to blood pressure. For this study, more than 347,000 people participated in it. This scale is the largest of this kind of study.

The discoveries include DNA changes in three genes that have much larger effects on blood pressure in the population than previously seen.

Dr. Louise Wain, from Leicester Institute of Precision Medicine, who co-led the genetic analysis in the study, said that this study provides essential information for precision medicine and allows patients to be treated with targeted therapy in earliest time to prevent the hypertension. And he also said that the first-class, high-performance computing facilities at the University of Leicester made this study to be able to set large scale of data.

High blood pressure – hypertension – is a major cause of cardiovascular disease and early death.

For the study, about 200 investigators from 15 countries participated. The teams investigated genotypes and health records to find the relevance between their genetic structure and cardiovascular health. Published in Nature Genetics, the research found variants in three genes that very small ratio of population have but is twice as much as effective to the hypertension.

Professor Patrick Munroe from Queen Mary’s University of London, the study author, said that this research can bring new development in treatment of hypertension and also can help us to understand the genetic knowledges and new biological pathways.

Professor Jeremy Pearson, associate medical director of the British Heart Foundation, which part-funded the research, also said that this study has identified genes that have larger effects on blood pressure than previously found.

The study was also funded by the National Institute for Health Research, the National Institute of Health, Wellcome Trust and Medical Research Council.


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