Role of Genetics in Immunity

According to a research from King’s College London, nearly 75 percent of immune traits are influenced by genes. The study adds to a developing body of evidence that our genetics significantly influence our immune system. The researchers, with the support of the NIHR Biomedical Research Centre at Guy’s and St Thomas’, analysed 23,000 immune characteristics in 497 adult female twins.

The researchers found that adaptive immune characteristics are mainly influenced by genetics. They also highlighted the importance of environmental factors such as diet, on determining the inmate immunity in adult life. The findings could result in a better understanding of the immune system and how it interacts with environmental factors. In addition, it could form the foundation of more research in a treatment of many diseases such as rheumatoid arthritis and psoriasis.

Dr Massimo Mansion, chief scientist from King’s College London said that adaptive immune responses appear to be more controlled by genome variations than he had previously thought. This means that people are likely to respond in an individualised way to an allergen or infection. This may have significant consequences for future personalised therapy.



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