Fatigue is Partly Influenced by Genes

Genes may contribute to why some people suffer from low energy levels or tire easily. According to recent research, being prone to fatigue is partly heritable, with genetic accounting for 8% of differences between individuals who were asked about their tiredness levels.
The study was led by Saskia Hagenaars and Dr. Vincent Deary, from the University of Edinburgh and Northumbria University respectively. They examine genetic make-up of 111,749 people who had reported whether they had low energy or felt tired in the two weeks before collection of data.
Also, the researcher also discovered that genetic predisposition to fatigue was also present in individuals genetically susceptible to various physical and mental health conditions, such as schizophrenia, depression, and smoking. Additionally, an overlap was identified between low levels of energy, and high levels of cholesterol and obesity.
According to the scientists, this raises the likelihood of a genetic linkage between fatigue and a susceptibility to physiological stress. The researchers also found that there was an overlap between a general tendency to poor health and tiredness.
The researchers said that most of the differences in tiredness are mainly environmental. The genetic data accounted for just 8.4% of people’s differences in tiredness. The findings were published in the journal Molecular Psychiatry.

Exercise and Genetics


According to the World Health Organization (WHO), after high blood pressure, high blood sugar and tobacco use, physical inactivity is the 4th leading risk factor for mortality in the world. Therefore, it is important for people to have a physically active lifestyle. But does exercise confer the same benefits on every person to the same extent?
Five universities in the US and Canada recruited 40 African-American families and 90 Caucasian families to the Heritage Family Study. The aim of the study was to investigate genetic role in the cardiovascular, hormonal and metabolic responses to the same twenty-week program of exercise the families undertook.
While race, sex, age had a minimal effect on the training effects, scientists noted in a 2007 report that was published in the American Journal of Epidemiology that there exist clear inter-individual differences in how people respond to regular exercise. These differences are aggregate in families.
The results of the study showed that genes influence how our bodies respond to physical activity. Genes play a big role in determining changes in body composition after exercise programs – such as body mass index, weight, or percentage of body fat.


Researchers Discover New Genetic Roots that Underpin Intelligence

Researchers have made a major development in understanding genes that influence intelligence. Using a large dataset of over 78,000 people with information on intelligence scores and DNA genotypes, the scientists discovered new biological routes and genes for intelligence.
Intelligence is among the most investigated human traits. Despite high heritability estimations of 80 percent in adulthood and 45 percent in childhood, only a few genes had earlier been linked to intelligence. According to a study that was published in the journal Nature Genetics, 52 genes determine human intelligence. Of these genes, 40 are new discoveries.
Also, the study showed that genetic impacts on intelligence are correlated with genetic impacts on educational accomplishment, and also, though less strongly, with intracranial volume, smoking cessation, height, autism spectrum disorder and head circumference in infancy. Inverse genetic associations were reported with depressive symptoms, Alzheimer’s disease, waist-to-hip ratio, waist circumference, schizophrenia, body mass index, and smoking history.
Scientists need to do more research to clarify the exact role of the discovered genes in intelligence. This will enable us to have a complete picture of how different genes result in intelligence differences. Currently, genetic results explain about 5 percent of the total differences in intelligence. While this is a large amount of difference for an intelligence trait, there is still a long road to go.

Genetics Determine our Eye Color

The eye color of a person results from pigmentation of the iris, which surrounds the pupil and helps to control the amount of light that can enter the eye. The color of the eye is mostly categorized as brown, green/hazel, or blue. Globally, brown is the most frequent color of the eye. Lighter eye colors, such as green and blue, are found mainly among people of European ancestry.
Colour of the eye is determined by variations in genes. Most genes that are associated with eye color play a vital role in the production, transport, and storage of a pigment known as melanin. Eye color is directly related to the quality and amount of melanin in the iris. Blue-eyed people have a small amount of melanin in the iris while brown-eyed people have a large amount of this pigment.
A specific area on chromosome 15 plays a key role in eye color. In this area, there are two genes that are located close together: HERC2 and OCA2. HERC2 gene contains a DNA segment that controls the activity of the OCA2 gene. OCA2 gene produces P protein that is involved in melanosomes maturation. Melanosomes are cellular structures that make and store melanin. Therefore, P protein plays an important role in the quality and amount of melanin available in the melanin. Less P protein produces less melanin in the iris, resulting in blue eyes. People with a large amount of melanin in their iris have brown eyes.